Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia

Neurology 2026

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Authors: Emma Louise Palatsides, Dibya Himali, Lachlan Cribb, Gina M. Peloso, Joanne Ryan, Qiong Yang, Charles S. Decarli, Alexa S. Beiser, Sudha Seshadri, Marina Cavuoto, Stephanie Yiallourou, Andrée‐Ann Baril
+2 more Jayandra J. Himali, Matthew Paul Pase
DOI: 10.1212/wnl.0000000000214773
Cited by: 2
References: 48

Abstract

BACKGROUND AND OBJECTIVES: haplotype was associated with cognition, brain volumes, or incident dementia. METHODS: and incident all-cause dementia risk. Data analysis spanned February 2023 to July 2025. RESULTS: = 0.012, N = 114,868, incident cases = 5,625) compared with homozygote majors. DISCUSSION: haplotype (homozygote minors or heterozygotes) was linked to better verbal episodic memory, larger hippocampal volumes, lower amounts of free water, and lower dementia risk. Further studies are required to replicate these results among diverse samples.

Fields of Study & Subjects

Ion Transport and Channel Regulation Cerebrospinal fluid and hydrocephalus Electrolyte and hormonal disorders

Publication details

Journal / source
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
106
Issue
7
Pages
e214773–e214773
Publication date
19 March 2026
Language
EN