Long-Term Exposure to Ambient Air Pollution and Incident Amyotrophic Lateral Sclerosis
Abstract
BACKGROUND AND OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology. Although a range of genetic and lifestyle factors have been implicated, the potential role of environmental airborne pollution exposure is uncertain. This study examined the association between long-term ambient exposure to air pollutants and the incidence of ALS in UK Biobank participants. METHODS: genotype. RESULTS: for nonlinearity >0.05). These results remained robust in various subgroup and sensitivity analyses. No evidence of gene-environment interaction was found. DISCUSSION: In this large population-based study with high statistical power, ambient air pollution was not a risk factor for the development of ALS.
Fields of Study & Subjects
Amyotrophic Lateral Sclerosis Research
Occupational exposure and asthma
Air Quality and Health Impacts
Publication details
- Journal / source
- Neurology
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 106
- Issue
- 8
- Pages
- e214858–e214858
- Publication date
- 3 April 2026
- Language
- EN