Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium

Neurology 2026

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Authors: Stephanie R Yiallourou, Crystal Wiedner, Qiong Yang, Andrée‐Ann Baril, Jeffrey R. Misialek, Christopher E. Kline, Stephanie Harrison, Rebecca Bernal, Alycia Bisson, Dibya Himali, Tobyn Chiu, Marina G. Cavuoto
+16 more Sonia Ancoli‐Israel, Qian Xiao, Okeanis Vaou, Antoine Weihs, Yue Leng, Rebecca F. Gottesman, Alexa S. Beiser, Oscar L. López, Pamela L. Lutsey, Shaun Purcell, Susan S Redline, Sudha S. Seshadri, Katie L. Stone, Kristine S. Yaffe, Matthew Paul Pase, Jayandra Jung Himali
DOI: 10.1212/wnl.0000000000218182
Cited by: 1
References: 41

Abstract

BACKGROUND AND OBJECTIVES: Sleep is multidimensional, and it remains unclear which aspects are most relevant to cognition and dementia risk. We aimed to apply a data-driven approach to identify clusters of sleep variables that reflect meaningful sleep composites and examined their association with cognition and dementia risk. METHODS: < 0.05. RESULTS: = 0.039) were associated with better global cognition. However, no significant associations were identified between the 9 sleep composites and dementia risk. DISCUSSION: Sleep composites were not significantly associated with dementia risk. However, longer, more consolidated sleep and stronger slow oscillation-spindle coupling were associated with cognitive performance. These composites may be useful in guiding further investigations of sleep-brain health relationships.

Fields of Study & Subjects

Sleep and related disorders Sleep and Work-Related Fatigue Sleep and Wakefulness Research

Publication details

Journal / source
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
107
Issue
4
Pages
e218182–e218182
Publication date
29 July 2026
Language
EN