Effect of Baseline ASPECTS on Tenecteplase Efficacy Before Thrombectomy in Acute Large-Vessel Occlusion Stroke

Neurology 2026

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Authors: Xianjun Huang, Junfeng Xu, Jeffrey L. Saver, Hongmei Xu, Guangxiong Yuan, Zhenyu Kong, Zhongfan Ruan, Chaoqun Li, Guangui Yang, Gregory W. Albers, Thanh N. Nguyen, Hongfei Sang
+4 more Zhongming Qiu, Qingwu Yang, Zhiming Zhou, Zibao Li
DOI: 10.1212/wnl.0000000000218467
Cited by: 1
References: 46

Abstract

BACKGROUND AND OBJECTIVES: The impact of ischemic extent on the efficacy and safety of intravenous thrombolysis before thrombectomy remains uncertain. The aim of this study was to evaluate whether the baseline ischemic extent, measured by the Alberta Stroke Program Early Computed Tomography Score (ASPECTS), modifies outcomes of intravenous tenecteplase administered before endovascular thrombectomy. METHODS: This was a post hoc analysis of the BRIDGE-TNK (thrombectomy with vs without rhTNK-tPA in stroke) trial, conducted across China from May 2022 to September 2024. We compared the efficacy and safety of intravenous tenecteplase plus thrombectomy vs thrombectomy alone in acute large-vessel occlusion stroke patients within 4.5 hours of last known well, stratified by baseline ASPECTS (

Fields of Study & Subjects

Acute Ischemic Stroke Management Blood Coagulation and Thrombosis Mechanisms Peripheral Artery Disease Management

Publication details

Journal / source
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
107
Issue
6
Pages
e218467–e218467
Publication date
20 August 2026
Language
EN