[Clinical application and mechanistic studies of psychedelics for treatment of depression: progress and future challenges].
Abstract
receptor-dependent hypothesis versus the TrkB neurotrophic pathway-dependent hypothesis. Despite the promising outlook, translational applications of these substances faces several key challenges, including psychedelic-related risks, incomplete mechanistic understanding, lack of standardized treatment protocols, and insufficient long-term safety data. Future research should focus on elucidating the underlying neurobiological mechanisms, developing non-hallucinogenic derivatives, establishing standardized treatment frameworks, and identifying precise biomarkers to advance this therapeutic approach toward safer, more standardized, and personalized clinical implementation.
Fields of Study & Subjects
Psychedelics and Drug Studies
Treatment of Major Depression
Tryptophan and brain disorders
Publication details
- Journal / source
- PubMed
- Volume
- 46
- Issue
- 1
- Pages
- 1–5
- Publication date
- 20 January 2026
- Language
- ZH