Identification of immune status subtypes and prognostic analysis of septic patients based on Th1/Th2 cytokine assays.

OBJECTIVES: Sepsis patients exhibit diverse immune states, making it crucial to identify subtypes with distinct inflammatory profiles through Th1/Th2 cytokine data for personalized treatment and improved prognosis. METHODS: We retrieved data from sepsis patients who underwent Th1/Th2 cytokine testing in Nanfang Hospital, Southern Medical University from June 1, 2020, to February 1, 2022. An unsupervised K-means clustering method classified participants based on Th1/Th2 cytokine levels, with the primary outcome being the 7-day mortality rate post-ICU admission. Cox proportional hazards and Restricted Mean Survival Time (RMST) analyses were utilized to explore survival outcomes. RESULTS: : 2.57-20.79). CONCLUSIONS: Septic patients in a protective immune response state (Cluster 1) exhibit better short-term prognoses, suggesting the importance of understanding inflammatory/immune states for precise treatment and improved outcomes.