Study on the association between triglyceride-glucose index and osteoarthritis based on NHANES

Objective To analyze the association between the triglyceride-glucose (TyG) index and osteoarthritis (OA).Methods Using data from the National Health and Nutrition Examination Survey of the United States from 2009 to 2020, multivariable Logistic regression and restricted cubic spline (RCS) were used to evaluate the relationship between the TyG index and OA, with threshold-effect analyses performed.Results Among 10,986 participants (1,484 with OA), multivariable Logistic regression showed a significant positive association between the TyG index and OA. After adjustment for age, sex, race, body-mass index, C-reactive protein, and other relevant covariates, each one-unit increase in the TyG index was associated with a 53% higher odds of OA [OR=1.53, 95%CI (1.38, 1.69)]. RCS analysis revealed a non-linear relationship (P