[Characteristics of the Pathogenic Bacteria Isolated from the Lower Respiratory Tract of the Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease].

Objective: To analyze the species distribution and in vitro susceptibility of pathogenic bacteria isolated from the lower respiratory tract of the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to provide guidance for the treatment of pulmonary infections in this kind of patients. Methods: The AECOPD patients with suspected lower respiratory tract sample infection from January 2015 to December 2024 were included. The data of species identification and in vitro drug susceptibility testing results of pathogenic bacteria isolated from the lower respiratory tract were retrospectively collected. The detection rate, species distribution, in vitro susceptibility of predominant species, and ratios of multidrug-resistant (MDR) bacteria were compared among different sample types. Data were analyzed using WHONET 5.6 and SPSS 26.0 software. Results: < 0.01). Conclusion: Gram-negative bacteria were the predominant pathogenic bacteria detected from the low respiratory tract of AECOPD patients, with a low isolation rate of fastidious bacteria. Non-sputum samples exhibited a higher detection rate of MDR bacteria.