Hepatectomy After Progressive Disease Following Chemotherapy for Colorectal Liver Metastases: A Japanese Nationwide Cohort Study

PURPOSE: We evaluated the postoperative outcomes of patients with progressive disease after systemic chemotherapy compared with those with controlled disease. METHODS: This retrospective study analyzed patients from the Colorectal Cancer Liver Metastasis Database, compiled by the Joint Committee of Liver Metastases Survey from Colorectal Cancer. Patients who received chemotherapy were categorized into complete response, partial response, stable disease, and progressive disease groups and further subdivided into resected and non-resected subgroups. Survival outcomes and prognostic factors were evaluated. RESULTS: The number of patients in the complete response/partial response, stable disease, and progressive disease groups was 867, 550, and 195, respectively. Among the progressive disease group, 111 patients (57%) underwent hepatectomy. Their postoperative 5 year overall survival rate was 42.7%, which was significantly lower than that of the resected-complete response/partial response (62.0%, p