Synthetic Study of C1–C13 Intermediate in Phoslactomycins and Leustroducsins
Abstract
Phoslactomycins and leustroducsins are highly functionalized polyketides. In this paper, we report the new synthetic method for the C1-C13 fragment. This method involves a Suzuki-Miyaura coupling reaction between the C3-C7 acetylene and C8-C13 iodoolefin, followed by construction of the lactone part. The C8-C9 diol is constructed by dihydroxylation in the late stage of the synthesis.
Fields of Study & Subjects
Organic Chemistry Synthesis Methods
Microbial Natural Products and Biosynthesis
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- Chemical and Pharmaceutical Bulletin
- Volume
- 74
- Issue
- 1
- Pages
- 79–89
- Publication date
- 13 January 2026
- Language
- EN