4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from Chaetomium brasiliense

Chemical and Pharmaceutical Bulletin 2026 Open access

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Authors: Shuntaro Morita, Sho Furumura, Yohei Morishita, Taro Ozaki, Hanako Fukano, Yoshihiko Hoshino, Aki Hirabayashi, Masato Suzuki, Yoshiteru Oshima, Teigo ASAI
DOI: 10.1248/cpb.c25-00729
Cited by: 0
References: 20

Abstract

A new depsidone, termed mollicellin Z2 (1), and three known mollicellins D, H, and I (2-4), were isolated from cultured Chaetomium brasiliense NBRC 6548 mycelia. The structure of 1 was determined from one dimensional (1D) and 2D-NMR and high resolution electron ionization (HREI)MS spectra. It is the first 4-desmethyl mollicellin analogue found to contain a C-7 prenyl group and is likely generated via a biosynthetic pathway that is distinct from those that produce the 27 known analogues. This is the first report of mollicellin derivatives with antibacterial activity against nontuberculous mycobacteria.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Microbial Metabolism and Applications Bioactive natural compounds

Publication details

Journal / source
Chemical and Pharmaceutical Bulletin
Volume
74
Issue
2
Pages
170–174
Publication date
12 February 2026
Language
EN