Asymmetric Aerobic Intramolecular Dearomative ortho Coupling of Tethered Phenols by Chromium-Salen Complex/Nitroxyl Radical Catalysis

Chemical and Pharmaceutical Bulletin 2026 Open access

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Authors: Shota Nagasawa, Nao Yokota, Shogo Fujiki, Yusuke Sasano, Yoshiharu Iwabuchi
DOI: 10.1248/cpb.c25-00762
Cited by: 0
References: 15

Abstract

Herein, we report the catalytic asymmetric intramolecular dearomative coupling of tethered phenols in ortho-para fashion under aerobic conditions. Cooperative catalysis with a chromium-salen complex/nitroxyl radical enabled the desired transformation to proceed at ambient temperature under oxygen atmosphere. A range of tethered phenols were efficiently converted into spirocyclic 2,4-dienones in moderate to good yields and enantioselectivities (up to 68% enantiomeric excess (ee)).

Fields of Study & Subjects

Oxidative Organic Chemistry Reactions Asymmetric Synthesis and Catalysis Axial and Atropisomeric Chirality Synthesis

Publication details

Journal / source
Chemical and Pharmaceutical Bulletin
Volume
74
Issue
1
Pages
127–131
Publication date
29 January 2026
Language
EN