Comparison of Atheroma Burden Changes Using Conventional vs. End-Diastolic Intravascular Ultrasound Segmentation ― Post Hoc Analysis of the PACMAN-AMI Study ―

Circulation Journal 2026 Open access

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Authors: Nathan Angelo Lecaros Yap, Christos V. Bourantas, Sylvain Losdat, Nicole Ng, Jonas Dominik Häner, I H Tanboga, Tatsuhiko Otsuka, Yasushi Ueki, Andreas Baumbach, Anthony Mathur, R Kakizaki, ERNEST F. SPITZER
+6 more Jouke Dijkstra, Thomas Engstrøm, David Spirk, Irene Lang, Konstantinos C. Koskinas, Lorenz Räber
DOI: 10.1253/circj.cj-25-0590
Cited by: 1
References: 32

Abstract

BACKGROUND: This study compared changes in percentage atheroma volume (PAV) using an end-diastolic (ED) intravascular ultrasound (IVUS) segmentation approach vs. the conventional 1-mm interval analysis in serial IVUS data from the PACMAN-AMI trial. METHODS AND RESULTS: , respectively [P=0.823]; PAV: 1.29% vs. 1.25%, respectively [P=0.911]). Biomarker correlations with TAV and PAV changes did not differ between approaches. CONCLUSIONS: ED- and 1-mm-based analyses demonstrated comparable treatment effects of alirocumab on plaque regression in PACMAN-AMI. These findings support the use of the less time-consuming 1-mm segmentation method in serial IVUS studies.

Fields of Study & Subjects

Cerebrovascular and Carotid Artery Diseases Coronary Interventions and Diagnostics Cardiovascular Health and Disease Prevention

Publication details

Journal / source
Circulation Journal
Publisher
Japanese Circulation Society
Volume
90
Issue
8
Pages
1010–1021
Publication date
3 March 2026
Language
EN