Determinants and Mechanisms of Postoperative Effort Intolerance in Suspected Lung Cancer ― An Exercise-Stress Echocardiography Study ―

Circulation Journal 2026 Open access

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Authors: Akane Tsuchiya, Hiroto Utsunomiya, Atsushi Kamigaichi, Yasuhiro Tsutani, Ayano Hamada, Makoto Takeuchi, Yohei Hyodo, Atsuo Mogami, Kosuke Takahari, Yusuke Ueda, Y. Miyata, Morihito Okada
+1 more Yukiko Nakano
DOI: 10.1253/circj.cj-25-0733
Cited by: 1
References: 28

Abstract

BACKGROUND: Decreased exercise tolerance after pulmonary resection for lung cancer is strongly associated with a poor prognosis, but its determinants remain underexplored. We investigated the mechanisms of postoperative effort intolerance in lung cancer using combined exercise-stress echocardiography and cardiopulmonary exercise testing (ESE-CPET). METHODS AND RESULTS: . Subgroup analysis showed greater changes in systolic pulmonary artery pressure during exercise (∆SPAP) and steeper postoperative MPAP/CO slopes in patients with ≥3 resected segments vs.

Fields of Study & Subjects

Lung Cancer Diagnosis and Treatment Cardiac Anesthesia and Surgical Outcomes Cancer Stress Anesthesia and Immune Response

Publication details

Journal / source
Circulation Journal
Publisher
Japanese Circulation Society
Volume
90
Issue
4
Pages
376–387
Publication date
17 February 2026
Language
EN