Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases

Circulation Journal 2026 Open access

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Authors: Sayuri Yamabe, Kiyomi Kayama, Yoshiro Tsuruta, Yu Kawada, Tatsuya Mizoguchi, Masashi Yokoi, Kento Mori, Tsuyoshi Ito, Kyoko Matsui, Shuichi Kitada, Toshihiko Goto, Masahiro Yasuda
+5 more Hitomi Kimura, Satoshi Koyama, Tsutomu Shinohara, Keiichi Itatani, Yoshihiro Seo
DOI: 10.1253/circj.cj-25-0786
Cited by: 1
References: 5

Abstract

BACKGROUND: In repaired tetralogy of Fallot (TOF) and related diseases, reoperation for pulmonary regurgitation (PR) may be delayed unless marked right ventricular (RV) enlargement is present. METHODS AND RESULTS: 32 patients with significant PR post-repair underwent catheterization and 4D flow MRI for reoperation evaluation. The Non-severe RV Dilation group (n=20) did not meet the surgical volume criteria, whereas the Severe RV Dilation group (n=12) did. The Non-severe RV Dilation group had higher biventricular filling pressures. The RV-Energy loss index in both groups was high. CONCLUSIONS: Diastolic dysfunction could serve as a therapeutic target in PR patients with heterogeneous etiologies.

Fields of Study & Subjects

Congenital Heart Disease Studies Cardiovascular Function and Risk Factors Pulmonary Hypertension Research and Treatments

Publication details

Journal / source
Circulation Journal
Publisher
Japanese Circulation Society
Volume
90
Issue
9
Pages
1299–1301
Publication date
19 January 2026
Language
EN