Pyrophosphate Scintigraphy Changes After Tafamidis Therapy ― Proposed Novel Index From Quantitative Single-Photon Emission Computed Tomography ―

Circulation Journal 2026 Open access

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Authors: Tsuneaki Yoshinaga, Shin Yanagisawa, Masatoshi Minamisawa, Ken Takasone, Yusuke Mochizuki, Yusuke Takahashi, Yukinori Okajima, Jun Koyama, Koichiro Kuwahara, Yasunari Fujinaga, Yoshiki Sekijima
DOI: 10.1253/circj.cj-25-1110
Cited by: 0
References: 4

Abstract

BACKGROUND: Because a disease-modifying therapy is now available, bone scintigraphy plays a crucial role in diagnosing transthyretin cardiac amyloidosis (ATTR-CM). METHODS AND RESULTS: We retrospectively analyzed 24 patients with ATTR-CM to determine the amyloid accumulation volume (AAV: mean standardized uptake value×volume) of the left ventricular wall. AAV showed a significant decrease (591.1±426.0 vs. 213.8±201.9, P

Fields of Study & Subjects

Amyloidosis: Diagnosis Treatment Outcomes Cardiac Imaging and Diagnostics Cardiac tumors and thrombi

Publication details

Journal / source
Circulation Journal
Volume
90
Issue
6
Pages
741–744
Publication date
13 February 2026
Language
EN