Distinct Metabolomic and Clinical Phenotypes of Depression in Heart Failure ― Pilot Exploratory Analysis ―

Circulation Journal 2026 Open access

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Authors: Yoshiharu Kinugasa, Hiroko Kamitani-Noguchi, Kensuke Nakamura, Masayuki Hirai, Midori Manba, Natsuko Ishiga, Takeshi Sota, Natsuko Nakayama, Tomoki Ota, Masahiko Kato, Kazuhiro Yamamoto
DOI: 10.1253/circj.cj-26-0058
Cited by: 1
References: 47

Abstract

BACKGROUND: Depression is common among patients with heart failure (HF) and worsens prognosis, but its metabolic heterogeneity remains unclear. METHODS AND RESULTS: Fifty HF patients completed the Patient Health Questionnaire-9 (PHQ-9) and underwent metabolomic profiling of 163 metabolites. Depressed patients (PHQ-9 score ≥5; n=26) were stratified using k-means clustering. Spearman's correlation with false discovery rate (FDR) correction (FDR

Fields of Study & Subjects

Metabolomics and Mass Spectrometry Studies Heart Failure Treatment and Management GDF15 and Related Biomarkers

Publication details

Journal / source
Circulation Journal
Publisher
Japanese Circulation Society
Volume
90
Issue
6
Pages
691–700
Publication date
23 April 2026
Language
EN