Trajectory of Multidimensional Frailty Across Recurrent Heart Failure Hospitalizations ― A Single-Center Longitudinal Cohort Study ―

Circulation Journal 2026 Open access

Read full text
Authors: Yuta Ozaki, Yusuke Uemura, Shigefumi Honda, Toru Kondo, Shingo Kazama, Kenji Takemoto, Masato Watarai, Toyoaki Murohara
DOI: 10.1253/circj.cj-26-0186
Cited by: 1
References: 26

Abstract

BACKGROUND: Heart failure (HF) is characterized by recurrent clinical deterioration, and multidimensional frailty (i.e., functional status, nutritional status, sarcopenia-related phenotypes, and cognitive impairment) is a key determinant of prognosis. We explored longitudinal changes in these multidimensional domains across recurrent hospitalizations for HF. METHODS AND RESULTS: This single-center retrospective cohort study analyzed 337 patients initially hospitalized for HF between 2016 and 2024 who subsequently experienced ≥1 rehospitalization (total 780 admissions). Longitudinal changes across repeated hospitalizations were evaluated using age- and sex-adjusted linear mixed-effects models. The median age was 83 years, and 47.2% were women. Across repeated hospitalizations, frailty and functional status worsened (Clinical Frailty Scale, β=0.40, P

Fields of Study & Subjects

Frailty in Older Adults Heart Failure Treatment and Management Chronic Disease Management Strategies

Publication details

Journal / source
Circulation Journal
Publisher
Japanese Circulation Society
Volume
90
Issue
11
Pages
1675-1681
Publication date
25 May 2026
Language
EN