Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation

Circulation Journal 2026 Open access

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Authors: Kosuke Takahari, Tatsuya Shiraki, Hidetaka Kioka, Daisuke Nakamura, Yasuhiro Akazawa, Kei Nakamoto, Yuki Kuramoto, Hibiki Mima, Fusako Sera, Yasuharu Takeda, Yasumasa Tsukamoto, Isamu Mizote
+5 more Yusuke Adachi, Tomoyo Hamana, Tomohito Ohtani, Shigeru Miyagawa, Yasushi Sakata
DOI: 10.1253/circj.cj-26-0427
Cited by: 1
References: 25

Abstract

BACKGROUND: Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear. METHODS AND RESULTS:

Fields of Study & Subjects

Transplantation: Methods and Outcomes Renal Transplantation Outcomes and Treatments Cardiac Fibrosis and Remodeling

Publication details

Journal / source
Circulation Journal
Publisher
Japanese Circulation Society
Volume
90
Issue
11
Pages
1596-1605
Publication date
20 August 2026
Language
EN