Risk Factors for Venous Thromboembolism in Advanced Non-Small Cell Lung Cancer ― A Nationwide Administrative Database Study ―
Abstract
Background: Non-small cell lung cancer (NSCLC) is associated with a high risk of venous thromboembolism (VTE). However, data on specific risk factors for VTE in patients with advanced NSCLC remain limited. Methods and Results: increase; 95% CI 1.009-1.048), previous VTE (HR 2.707; 95% CI 1.907-3.843), platinum-based chemotherapy (HR 1.217; 95% CI 1.051-1.410), anti-vascular endothelial growth factor agent (HR 1.763; 95% CI 1.458-2.132), heart failure (HR 1.677; 95% CI 1.432-1.965), and stroke/transient ischemic attack (HR 1.296; 95% CI 1.055-1.593). Conclusions: This large-scale study identified several significant risk factors for VTE in patients with advanced NSCLC. The findings suggest the need for risk-stratified monitoring and prophylactic strategies to reduce VTE-related complications in high-risk patients.
Fields of Study & Subjects
Venous Thromboembolism Diagnosis and Management
Cardiac tumors and thrombi
Inflammatory Biomarkers in Disease Prognosis
Publication details
- Journal / source
- Circulation Reports
- Publisher
- Japanese Circulation Society
- Volume
- 8
- Issue
- 4
- Pages
- 634–641
- Publication date
- 30 January 2026
- Language
- EN