Prognostic Factors and Risk Stratification in Malignant Tumor Patients With Sepsis: A Retrospective Cohort Study

BACKGROUND Sepsis is a life-threatening complication in cancer patients and a major contributor to ICU admission and mortality. Although tumor-related factors affect outcomes, the prognostic value of ICU-specific clinical parameters remains insufficiently explored. This study aimed to identify ICU-related predictors of mortality beyond tumor characteristics in cancer patients with sepsis. MATERIAL AND METHODS We conducted a single-center retrospective cohort study including 4301 cancer patients with sepsis. Independent predictors of 28-day mortality were identified using multivariable logistic regression. Model performance was evaluated using discrimination, calibration, decision curve analysis (DCA), and clinical impact curves. RESULTS Nine independent predictors of 28-day mortality were identified (all P