Association of Preoperative Neutrophil-to-Lymphocyte Ratio With Post-Dural Puncture Headache After Cesarean Delivery

BACKGROUND Post-dural puncture headache (PDPH) is a common complication of spinal anesthesia in cesarean delivery. While demographic and procedural factors are well recognized, the role of systemic inflammatory indices in pregnant women has not been clearly defined. MATERIAL AND METHODS This retrospective cohort study included 821 pregnant women who underwent elective cesarean delivery under spinal anesthesia between January 2020 and December 2024. PDPH was diagnosed using the ICHD-3 criteria. Preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI) were evaluated using correlation, logistic regression, and receiver operating characteristic (ROC) analyses. RESULTS PDPH occurred in 133 patients (16.2%). Median NLR values were lower in the PDPH group compared with controls (2.63 vs 3.82, P