Testosterone Effect on Anesthesia Depth in Micropenis Hypospadias Surgery: A Prospective Cohort Study

Objective: To investigate prospectively the effect of testosterone treatment applied to patients with micropenis for hypospadias surgery on the depth of general anesthesia during surgery.Another objective was to make recommendations for the awareness of patients who have testosterone treatment used for sex reassignment surgery under anesthesia in the early period. Methodology: The study was a prospective cohort study conducted by the Department of Anesthesiology, Intensive Care and Pain Management of Tekirdağ Namık Kemal University Hospital between September 2024 and December 2024 (four months). We recorded the effect of intramuscular testosterone treatment administered to patients with micropenis hypospadias two weeks prior to surgery on the depth of anesthesia (1.1-1.2 MAC), as well as intraoperative changes in bispectral index (BIS), heart rate (HR), and peak airway pressure (PIP) at 5, 15, 30, 45, and 60 minutes. Results: Statistical differences were found between Group-C (Control) (n=30) and Group-T (Testosterone) (n=11). Although the depth of anesthesia was found to be between normal values for general anesthesia (BIS 40-60) in both groups, statistical differences were found between BIS, HR, and PIP values. (p< 0.05). Conclusion: This trial was prospectively registered on September 13, 2024 in clinicaltrials.gov with trial number "NCT06606496".