Inflammatory Markers in Pediatric Bacterial Sepsis vs. SARS-CoV-2 Infection: A Retrospective Study.

PubMed 2026 Open access

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Authors: Antonio Andrusca, Cristina Maria Mihai, Alexandru Cosmin Pantazi, Simona Claudia Cambrea, Irina Ion, Emil Anton, Tatiana Chisnoiu, Ancuța Lupu, Mihaela Stoicescu, Florin Daniel Enache, Vasile Valeriu Lupu, Ileana Ion
DOI: 10.12865/chsj.51.03.11
Cited by: 0

Abstract

Early differentiation between bacterial sepsis and viral infection in pediatric patients is critical for timely and appropriate therapy. We compared the inflammatory markers C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR), and D-dimer in children with bacterial sepsis and those with SARS-CoV-2 infection to discern characteristic profiles. METHODS: We retrospectively analyzed 97 pediatric sepsis cases (culture-confirmed bacterial infections) and 100 pediatric COVID-19 cases (RT-PCR-confirmed SARS-CoV-2). The initial inflammatory marker levels were extracted from the medical records. Statistical comparisons of means and medians were performed, with significance set at p

Fields of Study & Subjects

Sepsis Diagnosis and Treatment COVID-19 Clinical Research Studies Inflammation biomarkers and pathways

Publication details

Journal / source
PubMed
Volume
51
Issue
3
Pages
390–397
Publication date
26 January 2026
Language
EN