A calf with concurrent infantile hemangioma and coronary artery fistula: notes on simultaneous onset

A female Holstein calf presented with clinical respiratory signs induced by a laryngeal mass, with an antemortem diagnosis of coronary artery fistula based on echocardiography and computed tomography. After surgical treatment, pathological examination of the mass revealed positive staining for Glut1 consistent with infantile hemangioma in humans. This was a rare case of an infantile hemangioma developing concurrently with a coronary artery fistula. To comprehensively investigate the genetic mutations involved in this concurrent occurrence, whole-genome DNA sequencing using next-generation sequencers was performed. Genetic analysis identified mutations in the VEGFA, NOTCH2, IHH, and PDGFβ genes, which might have contributed to the concurrent occurrence of infantile hemangioma and coronary artery fistula in this case.