Bezafibrate prolongs hypothermia induced by an A1 adenosine receptor agonist in CBA/N mice
Abstract
Understanding thermoregulation within the range of low body temperatures (Tb) in homeotherms is of special interest in various life science fields. Here, we report that mice exhibit long-lasting hypothermia induced by the administration of an A1 adenosine receptor (A1AR) agonist, N6-cyclohexyladenosine (CHA), in combination with pretreatment with bezafibrates (BZ), a peroxisome proliferator-activated receptor α (PPARα) agonist. Before the induction of hypothermia by CHA administration at a dose of 0.5 mg/kg, CBA/N mice were fed 0.5% BZ-supplemented food for 10 days at an ambient temperature of 23–24℃. Ten days after BZ treatment, intraperitoneal CHA administration induced low Tb (
Fields of Study & Subjects
Thermal Regulation in Medicine
Peroxisome Proliferator-Activated Receptors
Adipose Tissue and Metabolism
Publication details
- Journal / source
- Journal of Veterinary Medical Science
- Volume
- 88
- Issue
- 4
- Pages
- 573–580
- Publication date
- 1 January 2026
- Language
- EN