Etiology and clinical features of hypertransaminasemia in children: A retrospective study from a tertiary care center in Türkiye

Objective: This study aimed to investigate the etiology of hypertransaminasemia in children and to evaluate the clinical characteristics of patients based on age and underlying causes. Material and Methods: A total of 210 pediatric patients aged between 1 month and 18 years who presented to the Pediatric Gastroenterology Outpatient Clinic with hypertransaminasemia were retrospectively analyzed. Hypertransaminasemia was defined as AST >50 IU/L and ALT >45 IU/L on at least two separate occasions within two months. Results: The mean age of the patients was 5.36±5.30 years and 50.5% were female. At presentation, 30.5% were asymptomatic, with fever being the most common symptom (23.4%). Physical examination findings were normal in 53.8% of cases. Mean AST and ALT values were significantly higher in symptomatic patients compared to asymptomatic ones (p