Platelet-rich plasma, low-level light therapy and microneedling for hair loss : an integrative review and case study

This article explores platelet-rich plasma (PRP), low-level light therapy (LLLT), and microneedling as combined treatments for severe alopecia areata (AA) unresponsive to corticosteroids. Hair loss affects over 15 million adults in the UK and can cause significant psychological distress. AA, an immune-mediated non-scarring alopecia, may be triggered by infections or vaccination and often proves difficult to manage with standard therapies. We describe a 36-year-old patient who developed alopecia totalis following COVID-19 vaccination and failed topical steroid therapy. A multimodal protocol of monthly PRP sessions paired with LLLT and interspersed microneedling, supplemented by topical and oral agents, produced marked hair regrowth and improved scalp coverage. Current evidence supports each modality's ability to enhance follicular activity, while combination therapy appears synergistic. This case highlights the potential of regenerative, patient-centred approaches for refractory AA and underscores the need for further controlled studies to define optimal treatment strategies.