Serum Klotho as a feasible diagnostic biomarker for metabolic syndrome in Iraqi adults aged over 50 years
Abstract
Background: Metabolic Syndrome (MetS) is a cluster of cardiometabolic risk factors primarily driven by insulin resistance, with a high prevalence in older adult populations. Objectives: This study aimed to evaluate the diagnostic accuracy of serum Klotho Beta (KLB) and insulin as novel biomarkers for MetS in Iraqi adults over 50 years old. Materials and methods: This case-control study included 60 MetS patients and 30 healthy controls, recruited from Iraqi hospitals. MetS was diagnosed using harmonized IDF/AHA/NCEP ATP III criteria. Serum Klotho Beta and insulin levels were measured by ELISA. Results: Serum Klotho Beta levels were significantly lower in the MetS group (25.54±4.41 nmol/L) compared to controls (59.00±11.05 nmol/L, p
Fields of Study & Subjects
Diabetes
Cardiovascular Risks
and Lipoproteins
Adipokines
Inflammation
and Metabolic Diseases
Parathyroid Disorders and Treatments
Publication details
- Journal / source
- Journal of Associated Medical Sciences
- Volume
- 59
- Issue
- 2
- Pages
- 178–186
- Publication date
- 12 February 2026
- Language
- EN