The usefulness of endometrial receptivity biomarkers as predictors of IVF outcome

Background: Despite advances in assisted reproductive technology, predicting in vitro fertilization (IVF) success remains challenging. Objectives: This study aimed to investigate the relationship between endometrial receptivity biomarkers and Ovarian Sensitivity Index (OSI) as predictors of IVF outcomes. Materials and methods: A total of 72 women undergoing IVF treatment, between December 2023 and July 2024, participated in this study. Serum levels of MUC1, GDF-9, and HLA were measured, OSI was calculated, and pregnancy outcomes (β-hCG) were recorded. Participants were divided into two groups based on OSI (≤4 and >4), and biomarker levels were compared. Correlation analysis, ROC curves, and logistic regression models were used to assess predictive capabilities. Results: OSI showed strong predictive value (AUC=0.751, 95% CI: 0.613-0.859, p8 (sensitivity=52.63%, specificity=94.12%). Endometrial biomarkers showed limited individual predictive capacity (AUCs: MUC1=0.625, GDF-9=0.507, HLA=0.589). OSI retained significant association with pregnancy outcomes across all regression models (OR=1.19-1.38, p