Bis–aldehyde based Chitosan Schiff base Polymer: Evaluation of Thermal, Cytotoxic, Antibacterial, Antioxidant, Anticancer and Wound Healing Properties

Polymer composites based on natural polymer have received greater attention due to their biocompatible and biodegradable nature. Chitosan(CS) a natural polymer obtained from marine source extensively used for many biomedical applications. Chitosan is a bio-based polymer with comparable physico-chemical properties of cellulose. Hence, researchers have explored a number of chemical alterations in chitosan to enhance its characteristics and broaden its functional potential range. In this work, we report chitosan Schiff bases (CSB) were formed by interaction of CS with bis-aldehyde at room temperature and explore its biological properties. The synthesized compounds were characterized by various analytical techniques. Chitosan (CS) and its derivatives are garnering a lot of interest in a variety of settings. Higher solubility as compared to unmodified CS significantly improved biological studies such as antimicrobial activity against Klebsiella and Methicillin-resistant staphylococcus aureus (MRSA) and against yeasts (Candida albicans,Trichoderma viridae, and Aspergillus niger), paving the way for the potential use of these chemicals in the pharmaceutical industry as a means of preventing the spread of harmful microorganisms.