Evaluating the Active Chemical Compounds in Extracts from Various Medicinal Herbs used for the Treatment of Skin Rashes

Many countries use the herb to treat ailments. Antioxidants are beneficial for treating skin rashes. Calligonum comosum, Ziziphus spina-christi, and Ruta graveolens have historically treated skin rashes. Saudi Arabia and its neighbours utilise it extensively. The FTIR and GC-MS examined all three plant-specific water extracts. The three plants vary in phytosterol and phenolics. Numerous flavonoids and phenolic acids were identified. Ruta graveolens (N1), Calligonum comosum (N2), and Ziziphus spina-christi (N3) were tested for antibacterial activity utilising time-dependent growth inhibition. P. aeruginosa and Staphylococcus aureus growth curves treated with N1, N2, and N3 revealed bacterial growth and reproduction suppression. N1 and N3 inhibited test microorganisms’ concentration-dependently, with N2 inhibiting S. aureus by 94% and P. aeruginosa by 83% at MIC. N2 showed minimal effect at 0.5xMIC. S. aureus and P. aeruginosa are decreased by 91% and 85% at MIC and 65% and 61% at 0.5xMIC by N2 extract. In contrast, N1's 2xMIC and MIC against P. aeruginosa and S. aureus dropped 91%, 87%, 72%, and 59%. This research may reveal Calligonum comosum, Ziziphus spina-christi, and Ruta graveolens' bioactive substances, molecular processes, and therapeutic impacts on human health. This discovery has increased plant bioactivity understanding and medical uses.