Recent Advances in Transdermal Delivery: Correlating Characteristics of Nanoparticles with Permeability in Lipid-based Drug Delivery Systems
Abstract
Transdermal drug delivery provides a noninvasive alternative to oral administration, though its efficacy is limited by the stratum corneum barrier. Lipid-based drug delivery systems are increasingly used to address this challenge. This review evaluates the relationship between the physicochemical characteristics of lipid-based particles and their resulting transdermal permeability. A structured literature search of ScienceDirect, PubMed, and Google Scholar (2015-2025) was conducted to identify original research articles reporting quantitative in vivo and ex vivo skin permeability data. The study analyzed nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers (NLC) based on particle size, polydispersity index (PDI), and zeta potential. Smaller particle size (
Fields of Study & Subjects
Advancements in Transdermal Drug Delivery
Advanced Drug Delivery Systems
Oral Health Pathology and Treatment
Publication details
- Journal / source
- Journal of Environmental Nanotechnology
- Publisher
- Institute for Environmental Nanotechnology
- Volume
- 15
- Issue
- 1
- Pages
- 340–348
- Publication date
- 1 April 2026