Emphasizing the Cardioprotective Efficacy of Basella alba in an In vivo Model of Isoproterenol-Induced Cardiac Injury

Purpose of the Study: This study provides valuable insights into the cardioprotective effects of Basella alba in a rat model of isoproterenol-induced myocardial infarction (MI). The focus of the research was to explore how the methanolic extract of Basella alba (MEBA) can influence myocardial injury markers, oxidative stress, and inflammation, offering a potential natural therapeutic approach for MI. Materials and Methods: The study uses a rat model where thirty male Wistar rats are divided into five groups. These groups include a control group, an MI-induced group with isoproterenol, and treatment groups receiving atenolol and two different doses of MEBA 100 mg/kg and 200 mg/kg.,p.o. The animals are treated for 30 days before being administered isoproterenol, which is known to induce myocardial infarction by disrupting coronary blood flow and causing cardiac tissue damage. Results: Markers of myocardial injury such as LDH, CPK, AST, and ALT, were significantly reduced (p