[Exploring the regulatory mechanism of Sparassis latifolia polysaccharides on hepatic glucose metabolism disorders in mice based on transcriptomics].

PubMed 2026

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Authors: Er-Chen Yang, Feng-Ying Jia, Limin Zhang, Li-Yang Jin, Dao-Qin Ren, Yue Jiang, Yun Shao-jun, Cui-Ping Feng
DOI: 10.13294/j.aps.2026.0058
Cited by: 1

Abstract

). Additionally, SLPs up-regulated p-FOXO1 protein expression level and down-regulated phosphoenolpyruvate carboxykinase (PEPCK) protein expression level. These results suggest that SLPs can effectively improve hepatic glucose metabolism disorders in mice induced by a high-fat diet combined with STZ by activating the PI3K/AKT/FOXO1 signaling pathway, involving the inhibition of key gluconeogenic enzymes and promotion of glucose utilization.

Publication details

Journal / source
PubMed
Volume
78
Issue
3
Pages
653–664
Publication date
25 June 2026
Language
ZH