Relationship of adiponectin and human placental lactogen with gestational diabetes mellitus and neonatal birth weight

Objective To investigate the relationship between adiponectin (APN) and human placental lactogen (hPL) levels in maternal peripheral blood, umbilical cord blood, and amniotic fluid and the occurrence of gestational diabetes mellitus (GDM) and neonatal birth weight, and to analyze the correlation between APN and hPL. Methods A total of 41 pregnant women with GDM who delivered at the West Coast Campus of The Affiliated Hospital of Qingdao University between January and May 2023 were included in the GDM group, and 41 healthy pregnant women who delivered during the same period were included in the control group. APN and hPL levels in maternal peripheral blood, umbilical cord blood, and amniotic fluid were measured and compared between the two groups. Correlations between APN and hPL, as well as between APN, hPL, and neonatal birth weight, were analyzed using Spearman’s correlation analysis. Results The levels of APN in maternal peripheral blood, amniotic fluid, and umbilical cord blood, and the level of hPL in umbilical cord blood, were significantly lower in the GDM group than in the control group (t=-2.956--2.436,P