Sedative effect of dexmedetomidine nasal spray combined with midazolam oral solution in children before surgery

Objective To investigate the sedative effect of dexmedetomidine nasal spray combined with midazolam oral solution in children before surgery. Methods A total of 60 children who underwent elective surgery in the Department of Oral and Maxillofacial Surgery at our hospital were enrolled and divided into dexmedetomidine group (group D) and dexmedetomidine+midazolam group (group DM), with 30 children in each group. The children in group D were given dexmedetomidine nasal spray before surgery, and those in group DM were given dexmedetomidine nasal spray combined with midazolam oral solution before surgery. Ramsay sedation score and PSAS score were recorded at 45 min after administration, and Frankl score was recorded at the time of venipuncture; perioperative adverse reactions were also recorded; the 5-minute electrocardiographic RR interval was collec-ted from each child on day 1 before surgery (T0) and after entering the surgical room in a supine position (T1) for heart rate variability (HRV) analysis. Results At 45 min after drug administration, compared with group D, group DM had significantly hig-her Ramsay sedation score and Frankl score during venipuncture and a significantly lower PSAS score (t=-4.26-5.77,P