Association between coagulation function in the acute stage and mortality within one week after admission in patients with severe traumatic brain injury

Objective To investigate the association between coagulation function in the acute stage and in-hospital mortality within one week after admission in patients with severe traumatic brain injury (sTBI). Methods A total of 412 patients with sTBI who were admitted to our hospital from June 2016 to March 2021 were enrolled, and according to their prognosis at 1 week after admission, they were divided into survival group with 350 patients and death group with 62 patients. The two groups were compared in terms of baseline data, Glasgow Coma Scale (GCS) score on admission, and coagulation parameters on admission. A binary logistic regression analysis was performed for significantly different indicators to identify the influencing factors for in-hospital mortality within one week. Results There were significant differences between the two groups in GCS score, the le-vels of fibrinogen, fibrinogen degradation products, and D-dimer in plasma, activated partial thromboplastin time, international normalized ratio, and platelet count on admission (t=-13.11-8.83,P