Reliability of diffuse optical spectroscopies for evaluation of cerebral hemometabolic stress in children with sickle cell anemia

Biomedical Optics Express 2026 Open access

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Authors: Giovani Martins, Rowan Brothers, Kristin Wubbena, Mariam M. Akbar, Michael Arrington, Katherine B. Turrentine, Sydney E. Triplett, Hongting Zhao, Tara M. Urner, Shasha Bai, Amy Tang, Kirshma Khemani
+3 more Beatrice Gee, R. Clark Brown, Erin M. Buckley
DOI: 10.1364/boe.582416
Cited by: 1
References: 34

Abstract

Diffuse optical spectroscopies are promising non-invasive optical techniques that may provide a point-of-care tool to evaluate cerebral hemometabolic stress. This study quantifies the intra- and inter-operator reliability of a battery of cerebral hemometabolic parameters quantified with diffuse correlation spectroscopy (DCS) and frequency-domain near-infrared spectroscopy (FDNIRS) in children with sickle cell anemia. For measures of cerebral blood flow, oxygen extraction fraction, metabolic rate of oxygen, and cerebral blood volume, we found inter-operator concordance correlation coefficients (CCC) ranging from 0.45 to 0.97, intra-operator CCCs ranging from 0.81 to 0.98, and a median coefficient of variation < 16%.

Fields of Study & Subjects

Optical Imaging and Spectroscopy Techniques Spectroscopy Techniques in Biomedical and Chemical Research Photoacoustic and Ultrasonic Imaging

Publication details

Journal / source
Biomedical Optics Express
Publisher
Optica Publishing Group
Volume
17
Issue
3
Pages
1152–1152
Publication date
23 January 2026
Language
EN