["Tiaoshen Tongluo" electroacupuncture improves learning-memory ability by regulating microglial polarization via the Nrf2/TREM2 signaling pathway in rats with cerebral ischemia-reperfusion injury].

PubMed 2026

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Authors: Rong Shi, Tie-Ming Ma, Shi-Jing Sun, Jing Jiang, Jia-xin Li, Qiong Wu, Zi-Xi Zhou, Jia-Wei Zhang, Rui-Rui Yang, Xitong Zhao, Jun-Jie Ma, Xiaoqing Zhang
+1 more Yi-Ran Chen
DOI: 10.13702/j.1000-0607.20251014
Cited by: 1

Abstract

OBJECTIVES: To observe the effect of "Tiaoshen Tongluo"(mind regulation and meridian-collateral dredging) electroacupuncture (EA) on the nuclear factor erythroid 2-related factor 2 (Nrf2)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling pathway and hippocampal microglial polarization in rats with learning-memory impairment induced by middle cerebral artery occlusion/reperfusion (MCAO/R). METHODS: (M2 type) positive cells in the hippocampal tissue. Western blot was used to measure the relative protein expression levels of Nrf2, TREM2, DNAX activator protein 12(DAP12), tumor necrosis factor-α(TNF-α) and transforming growth factor-β(TGF-β) in the hippocampal tissue. RESULTS:

Publication details

Journal / source
PubMed
Volume
51
Issue
8
Pages
1022–1032
Publication date
25 August 2026
Language
ZH