Mother and child health 4.5 years after gestational diabetes mellitus managed using tight or less tight targets for glycaemic control: Post-hoc follow-up study of the TARGET trial

PLoS Medicine 2026 Open access

Read full text
Authors: Lisa J. Douglas, Greg D. Gamble, Jane Elizabeth Harding, Deborah Samuel, Carl L. Eagleton, Jane M. Alsweiler, Trecia Ann Wouldes, Benjamin Thompson, Christopher J. D. McKinlay, Caroline A Crowther
DOI: 10.1371/journal.pmed.1004635
Cited by: 1
References: 15

Abstract

BACKGROUND: Optimal glycaemic targets for women with gestational diabetes mellitus (GDM) are unclear. The aim of this study was to compare maternal and child health 4.5 years after women with GDM had been randomised to use tight or less tight targets for glycaemic control during their pregnancy. METHODS AND FINDINGS: The TARGET trial was a stepped-wedge, cluster-randomised trial conducted between May 29, 2015 and November 7, 2017 at 10 hospitals in New Zealand. All hospitals were initially allocated to use less tight glycaemic treatment targets (fasting plasma glucose (FPG)

Fields of Study & Subjects

Gestational Diabetes Research and Management Diabetes Treatment and Management Diabetes Management and Research

Publication details

Journal / source
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Volume
23
Issue
2
Pages
e1004635–e1004635
Publication date
3 February 2026
Language
EN