Context matters: Causality and global epidemiology of proton pump inhibitor safety

PLoS Medicine 2026 Open access

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Authors: Shinji Okabayashi, Gilaad G. Kaplan
DOI: 10.1371/journal.pmed.1004862
Cited by: 0
References: 11

Abstract

Proton pump inhibitors revolutionized acid-related disorder therapy, yet widespread overuse has raised concerns about long-term safety. A recent study in PLOS Medicine presents new evidence assessing whether links between their prolonged use and upper gastrointestinal cancer are causal.

Fields of Study & Subjects

Gastroesophageal reflux and treatments Helicobacter pylori-related gastroenterology studies Esophageal Cancer Research and Treatment

Publication details

Journal / source
PLoS Medicine
Volume
23
Issue
1
Pages
e1004862–e1004862
Publication date
7 January 2026
Language
EN