Missing tissue, missing data: Resolving brain volume loss caused by anti-amyloid therapies

PLoS Medicine 2026 Open access

Read full text
Authors: Francesca M. Alves, Scott Ayton
DOI: 10.1371/journal.pmed.1004880
Cited by: 1
References: 12

Abstract

Anti-amyloid drugs modestly slow Alzheimer's disease progression, albeit with uncertainty of sustained benefit, particularly as they cause paradoxical acceleration of brain volume changes. Here, we examine explanations for these volume changes and argue for transparent release of clinical trial data.

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Cerebrospinal fluid and hydrocephalus

Publication details

Journal / source
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Volume
23
Issue
1
Pages
e1004880–e1004880
Publication date
20 January 2026
Language
EN