Gene-environment equivalence: The fundamental principle of Mendelian randomization

PLoS Medicine 2026 Open access

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Authors: George Davey Smith, Gibran Hemani, Shah Ebrahim
DOI: 10.1371/journal.pmed.1005013
Cited by: 10
References: 13

Abstract

The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers, and editors of gene-environment equivalence, the fundamental principle of MR.

Fields of Study & Subjects

Genetic Associations and Epidemiology Evolution and Genetic Dynamics Genomic variations and chromosomal abnormalities

Publication details

Journal / source
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Volume
23
Issue
3
Pages
e1005013–e1005013
Publication date
13 March 2026
Language
EN