Splenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture

PLoS neglected tropical diseases 2026 Open access

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Authors: Ghania Benabdelmoumen, Oula Itani, Valentin Joste, Sandrine Houzé, David Hardy, Florent Bavozet, Moussa Sylla, Steven Kho, Nicholas M. Anstey, Paul Henri Consigny, Abdoulaye Sissoko, Pierre Buffet
DOI: 10.1371/journal.pntd.0013897
Cited by: 1
References: 17

Abstract

A 35-year-old man had splenic rupture just after starting antimalarial treatment with atovaquone-proguanil followed by artesunate for acute Plasmodium ovale sensu lato infection. Spleen histology showed a 10-fold accumulation of intact P. ovale s.l.-infected erythrocytes in the spleen parenchyma compared to the general circulation. Infected erythrocytes also accumulated in small extra-splenic blood vessels, suggesting cytoadherence.

Fields of Study & Subjects

Malaria Research and Control Hematological disorders and diagnostics Abdominal Trauma and Injuries

Publication details

Journal / source
PLoS neglected tropical diseases
Publisher
Public Library of Science (PLoS)
Volume
20
Issue
1
Pages
e0013897–e0013897
Publication date
8 January 2026
Language
EN