Prognostic value of blood glucose trajectories in critically ill patients with intracerebral hemorrhage: A retrospective cohort study
Abstract
BACKGROUND: Abnormal glucose regulation is common in critically ill patients with intracerebral hemorrhage (ICH), but the prognostic relevance of early glucose patterns remains unclear. We aimed to identify early blood glucose trajectories in ICU patients with ICH and evaluate their association with short-term mortality. METHODS: Adult patients with ICH were identified from the MIMIC-IV database. Latent class analysis was applied to blood glucose measurements obtained within the first 36 hours after ICU admission to identify distinct glucose trajectory classes. Cox proportional hazards models were used to assess the association between glucose trajectories and 28-day in-hospital mortality with multivariable adjustment. A 36-hour landmark analysis and sensitivity analyses including patients with ICU length of stay
Fields of Study & Subjects
Hyperglycemia and glycemic control in critically ill and hospitalized patients
Intracerebral and Subarachnoid Hemorrhage Research
Trauma
Hemostasis
Coagulopathy
Resuscitation
Publication details
- Journal / source
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Volume
- 21
- Issue
- 2
- Pages
- e0342745–e0342745
- Publication date
- 24 February 2026
- Language
- EN