Transcranial direct current stimulation with Bosu-ball training increases cortical activation and improves ankle-foot function among individuals with chronic ankle instability: A randomized controlled trial

OBJECTIVES: This study explored the effects of High-definition transcranial direct current stimulation (HD-tDCS) with Bosu-ball training on cortical activation and ankle-foot function among individuals with chronic ankle instability (CAI). DESIGN: Single-blind randomized sham-controlled trial. SETTING: Biomechanics laboratory. METHODS: Thirty-seven participants were allocated to tDCS+Bosu group (n=19) and Bosu group (n=18), received 6-week active or sham HD-tDCS with Bosu ball training. Change values of oxyhemoglobin concentration (ΔHbO2) and Foot and Ankle Ability Measure (FAAM) were measured pre- and post-intervention. Two-way analysis of variance and Pearson correlation analysis were applied. RESULTS: We detected significant group-by-time interactions in ΔHbO2 for the affected and non-affected side premotor cortex and supplementary motor area (PMC & SMA, channel 4: P=0.048; channel 14: P=0.047) and the affected side primary motor cortex (M1, channel 6: P=0.049), and significant time effects for the affected and non-affected side PMC & SMA (channel 2: P=0.043; channel 12: P=0.047), M1 (channel 5: P=0.041; channel 15: P=0.027; channel 16: P=0.049), primary somatosensory cortex (S1, channel 7: P=0.039; channel 17: P=0.043) and somatosensory association cortex (SAC, channel 8: P=0.021; channel 19: P=0.035). We detected significant interaction in the FAAM Sports subscale (P=0.046), and significant time effect in the FAAM Activities of Daily Living subscale (ADL subscale) (P