Association of leuko-glycemic index with mortality in ICU patients with Acute kidney injury: A retrospective multicenter cohort study

PLoS ONE 2026 Open access

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Authors: Xuejin Ye, Sheng Chen, Lin Guo, Xiaohan Ma, Lingling Wu, Yiwen Li, Ting Zhang, Peng Jiang (16544), Hongjun Gao
DOI: 10.1371/journal.pone.0350811
Cited by: 1
References: 17

Abstract

BACKGROUND: Acute kidney injury (AKI) complicates the course of critical illness and carries high short- and long-term mortality rates; however, reliable early prognostic markers remain limited. The leuko-glycemic index (LGI), the product of white blood cell counts and blood glucose, has shown prognostic value in other acute conditions; however, its role in intensive care unit (ICU) patients with AKI remains unexplored. METHODS: In this multicenter retrospective cohort study, we analyzed 112,235 adult ICU admissions from the MIMIC-IV (n = 54,840) and eICU-CRD (n = 57,395) databases. Patients with multiple ICU stays and those aged

Fields of Study & Subjects

Hyperglycemia and glycemic control in critically ill and hospitalized patients Acute Kidney Injury Research Sepsis Diagnosis and Treatment

Publication details

Journal / source
PLoS ONE
Publisher
Public Library of Science (PLoS)
Volume
21
Issue
6
Pages
e0350811–e0350811
Publication date
4 June 2026
Language
EN