POTENSI PENGINDUKSI APOPTOSIS SENYAWA NIKOTINIL DIBUTIL GLUTAMAT ESTER TERHADAP SEL KANKER T47D
Abstract
Nicotinil Dibuthyl Glutamate Ester (NDBGE) is a synthetic compound that is an analog of antibiotic UK3A from mycelium of Streptomyces sp.517-02. This compound was estimated to have anticancer activity similar to UK-3A. The aim of this research was to know the NDBGEs apoptotic inducing potency to human breast cancer T47D in vitro. DMEM + 1% PS + 10% FBS was added to human breast cancer T47D cells until cell concentration reached 1-5x/ 05eells/ml. NDBGE then was diluted by DMSO until 100ppm concentration. Propidium iodide with 50pg/m1 concentration was added to the T47D cells. The analysis was conducted by flow cytometry method. The result was that the apoptosis percentage of the cells was 12,35%.
Fields of Study & Subjects
Biopolymer Synthesis and Applications
Tannin
Tannase and Anticancer Activities
Cancer and biochemical research
Publication details
- Journal / source
- Widyariset
- Publisher
- National Research and Innovation Agency
- Volume
- 12
- Issue
- 1
- Pages
- 149–154
- Publication date
- 18 August 2026
- Language
- ID