Olink Proteomic Research in Colorectal Cancer: Redefining Minimally Invasive Surgery through Biomarker-driven Insights

Cancer Screening and Prevention 2026 Open access

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Authors: Zhenting Zhao, Nan Wang, Pengyue Zhao
DOI: 10.14218/csp.2026.00029
Cited by: 1

Abstract

The study by Yan and colleagues in the Journal of Proteome Research (2025) represents a valuable contribution to the emerging integration of molecular profiling in surgical oncology.1 By employing high-fidelity Olink proteomic profiling, the research provides the first plasma proteomic comparison between Endoscopic Super-Minimally Invasive Surgery (ESMIS) and laparoscopic surgery (LS) for colorectal cancer (CRC), moving beyond traditional clinical metrics to propose a data-driven framework for understanding surgical trauma and tumor biology.The identification of candidate diagnostic biomarkers (AMN, LRP1, FOXO1, PTPRJ) and surgery-specific injury markers (CALCA, PDGFC) offers tan

Fields of Study & Subjects

Mechanisms of cancer metastasis Colorectal Cancer Surgical Treatments Cancer Stress Anesthesia and Immune Response

Publication details

Journal / source
Cancer Screening and Prevention
Publisher
Xia & He Publishing
Volume
000
Issue
000
Pages
000–000
Publication date
12 May 2026
Language
EN